Establishment of intestinal homeostasis during the neonatal period

Comment by InpharmD Researcher

The journal Cancers had the highest number of publications, while Cancer Research was the most frequently cited journal. Molecular, biology, immunology, medicine and genetics were the main research disciplines in the field of CAFs. Key directions in CAFs research encompassed the study of transforming growth factor-β, Fibroblast Activation Protein, breast cancer, as well as growth and metastasis. The findings from the analysis of keyword co-occurrence and literature co-citation have revealed several emerging hotspots and trends within the field of CAFs. These include STAT3, multidrug resistance, pancreatic ductal adenocarcinoma, pan-cancer analysis, preclinical evaluation, ionizing radiation, and gold nanoparticles.

Targeting CAFs is anticipated to be a novel and effective strategy for cancer treatment. This study provides a comprehensive overview of the existing research on CAFs from 2001 to 2022, utilizing bibliometric analysis. The study identified the prominent areas of investigation and anticipated future research directions, with the aim of providing valuable insights and recommendations for future studies in the field of CAFs.

Background

Cancer-associated fibroblasts (CAFs) constitute an important component of the tumor microenvironment, participating in various facets of cancer advancement and being recognized as contributors to tumor immune evasion. What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build.

The role of CAFs in various tumor types has attracted increasing attention recently. In this work, we conducted a comprehensive bibliometric analysis to uncover research trajectories and highlight emerging areas in the field of CAFs. What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build. A systematic search was performed within the Web of Science Core Collection to identify articles/reviews on CAFs published between 2000 and 2023.

Leveraging advanced bibliometric tools such as VOSviewer, CiteSpace, and online website, we examined and visualized publication trends, geographic contributions, institutional affiliations, journal prominence, author collaborations, and noteworthy references, keywords, and genes. What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build. Our analysis included 5,190 publications, indicating a rapid growth trend in both annual publications and citations related to CAFs.

China and the United States emerged as the foremost contributors in terms of publications, funding agencies, and international collaborations. Breast cancer was the most studied tumor, followed by colorectal cancer, pancreatic cancer, prostate cancer, and gastric cancer. What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build. Based on co-occurrence and bursting keywords, we identified the following research topics including immune cells (T cells, B-cells, tumor-associated macrophages), tumor immune microenvironment (antitumor immunity, immune infiltration, immunosuppression).

Relevant Prescribing Information

immunotherapy (PD-L1), microRNAs (miRNA), extracellular vesicles (exosome), multiple tumors (pancreatic ductal adenocarcinoma, bladder cancer, head and neck squamous cell carcinoma), antitumor agents (gemcitabine, cisplatin resistance), bioinformatics (pan-cancer), epithelial-mesenchymal transition (stemness), FAPI PET/CT, DNA methylation, etc., may receive sustained attention in the future. Furthermore, TGFB1, IL-6, TNF, TP53, and VEGFA emerged as the top 5 genes that have garnered the greatest research attention in the field of CAFs. The KEGG enrichment analysis highlighted that the top 20 most studied genes were mainly associated with HIF-1 and Toll-like receptor signaling pathways. Discussion: In sum, our bibliometric analysis offers a comprehensive overview of the research landscape in the field of CAFs. It encompasses the current state, evolving patterns, and prospective avenues of exploration, with special attention to the potential advancements in tumor immune microenvironment. What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build What are therapeutic alternatives for Azacitidine for Injection? Editing inquiry in android latest build.

Our analysis included 1836 publications spanning 1999 to 2022, indicating a growing trend in both annual publications and citations related to NAC in bladder cancer. The United States emerged as the predominant contributor in terms of publications, citations, and international collaborations. The University of Texas was the leading institution in publication output. "Urologic Oncology Seminars and Original Investigations" was the primary publishing journal, while "European Urology" boasted the highest impact factor. Shariat, Shahrokh F., and Grossman, H.B., were identified as the most prolific and co-cited authors, respectively. Keyword analysis revealed both frequency of occurrence and citation bursts, highlighting areas of concentrated study. Notably, the integration of immunochemotherapy is projected to experience substantial growth in forthcoming research.

Literature Review

A search of the published medical literature revealed 1 study investigating the researchable question:

Establishment of intestinal homeostasis during the neonatal period

Level of evidence

B - One high-quality study or multiple studies with limitations Read more→

Please see Table 1 for your response.

Enter title in bold, with all first words capitalized, and without a reference number
Design	Objective terms describing the type of study (randomized, uncontrolled, retrospective, placebo-controlled, cross-over, etc.); N= (total subjects)
Objective	State the objective (purpose) of the study using the author’s language(usually beginning with “To” and without a period, assuming a non-complete sentence)
Study Groups	Only the separate groups and their cohort number (n) should be listed. You can describe more details of the cohorts in the methods section so this section can stay very succinct.
Inclusion Criteria	Include relevant inclusion criteria (not a comprehensive list).
Exclusion Criteria	Include relevant exclusion criteria (not a comprehensive list).
Methods	This is our most important section. Data collection and any other information needed to understand the results is presented. Any loose ends from all other sections are tied up here, as concisely as possible.
Duration	Include the duration of the trial as a whole, as well as the duration of the interventions.
Outcome Measures	If the primary outcome measure isn’t explicit from the study, all outcome measures applicable to the inquiry can be listed in this section. If the primary outcome measure is explicit, then make separate sections for ‘Primary’ and ‘Secondary’ Outcome Measures. All outcome measures listed should correlate directly/exactly with the results presented later.
Baseline Characteristics		A	B
	Age, years
	Female
	White
	---
	Include relevant baseline characteristics that will provide a general (big picture) view of the patients in the study.
Results	Endpoint	A	B	p-Value
	----
	----
	All results listed should correlate directly/exactly with the outcome measures presented previously.Results that do not have to do with the inquiry should not be included; just the stated outcomes need corresponding results. Tables are encouraged to display the most info using the least space/words.
Adverse Events	Common Adverse Events: (or those deemed frequent; if not listed in study, use N/A or “Not disclosed”)
	Serious Adverse Events: (or those deemed high risk; if not listed in study, use N/A or “Not disclosed”)
	Percentage that Discontinued due to Adverse Events: (if not listed in study, use N/A or “Not disclosed”)
Study Author Conclusions	Copy and paste the author’s conclusions on the question at hand, using full sentences. Don’t include any conclusions that don’t correspond to results we list.
InpharmD Researcher Critique	As the expert, add 1-2 sentences on strengths, weaknesses, and takeaways from this study. Focus on insight as “more research is needed” is obvious.