InpharmD™





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What is InpharmD™?


Literature searching is tedious. InpharmD™ is here to help.

Clinical pharmacists can ask any question, anytime, from anywhere, and we’ll perform a custom literature search.

(And a 32% chance it’s already been asked.)


25,894

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Customer Satisfaction Rate

This is how InpharmD™ transforms LITERATURE.

What's Being Asked...

Measurable Residual Disease-Guided Therapy in Newly Diagnosed Myeloma
Can piperacillin and tazobactam (Zosyn) be infused with Lactated Ringers?
what are the therapeutic alternatives for the new drug 50% & 60*2 (MFR >12) and (GDF/20) pottasium (100mg/ml)?
Exploring the links between gut microbiota and excitatory and inhibitory brain processes in alcohol use disorder: A T...
The effect of acupressure on pain reduction during first stage of labour

What would you like to ask InpharmD™?

InpharmD's Answer GPT's Answer

Author:Neil Patel, PharmD, BCPS + InpharmD™ AI

INTRODUCTION BY INPHARMD™ RESEARCHER

Background: Measurable residual disease (MRD) is a major prognostic factor in newly diagnosed multiple myeloma. An assessment of an MRD-guided consolidation strategy in patients who are eligible for autologous stem-cell transplantation (ASCT) may be useful. Methods: In this phase 3 trial, we randomly assigned transplantation-eligible patients with newly diagnosed myeloma who had completed induction therapy with isatuximab, carfilzomib, lenalidomide, and dexamethasone (Isa-KRd) to receive c...

Background: Measurable residual disease (MRD) is a major prognostic factor in newly diagnosed multiple myeloma. An assessment of an MRD-guided consolidation strategy in patients who are eligible for autologous stem-cell transplantation (ASCT) may be useful. Methods: In this phase 3 trial, we randomly assigned transplantation-eligible patients with newly diagnosed myeloma who had completed induction therapy with isatuximab, carfilzomib, lenalidomide, and dexamethasone (Isa-KRd) to receive consolidation therapy according to their MRD status. Patients who were MRD-negative at 10-5 sensitivity (i.e., <1 cancer cell per 100,000 normal cells, as assessed by next-generation sequencing were assigned to undergo ASCT and receive Isa-KRd for two cycles (ASCT group) or to receive Isa-KRd for six cycles (Isa-KRd group). Patients who were MRD-positive at 10-5 sensitivity were assigned to undergo tandem ASCT (two ASCTs within a short period; tandem ASCT group) or to undergo ASCT and receive Isa...

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A search of the published medical literature revealed 1 study investigating the researchable question:

Measurable Residual Disease-Guided Therapy in Newly Diagnosed Myeloma

Level of evidence
B - One high-quality study or multiple studies with limitations  

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InpharmD's Answer GPT's Answer

Author:gabrielle pak, PharmD, BCPS + InpharmD™ AI

INTRODUCTION BY INPHARMD™ RESEARCHER

​​The manufacturer of Zosyn states Lactated Ringer's Solution is compatible only with reformulated Zosyn containing EDTA and is compatible with co-administration via a Y-site. Trissel's IV compatibility database notes the older formulation without the added components (most generic products) is incompatible with Lactated Ringer's. Thus, the newer formulation is the only form of the drug mixed with this diluent. A study that tested the physical compatibility of Lactated Ringer's found compatib...

Wyeth, the manufacturer of Zosyn, states Lactated Ringer's Solution is compatible only with reformulated Zosyn containing EDTA and is compatible with co-administration via a Y-site. Many generic formulations (e.g., Apotex) do not contain EDTA. [1, 2] Trissel's IV compatibility database notes the older formulation without the added components (most generic products) is incompatible with Lactated Ringer's. Ensure that the newer formulation is the only form of the drug mixed with Lactated Ringer's. [3] A 2019 study that tested the physical compatibility of Lactated Ringer's with 94 medications found incompatibilities with ciprofloxacin, cyclosporine, diazepam, ketamine, lorazepam, nitroglycerin, phenytoin, and propofol after 4 hours at room temperature. This study surprisingly found compatibility with ceftriaxone, amphotericin B, and piperacillin-tazobactam, which all previously were thought to be incompatible with LR (See Tables 1 and 2). [4] The study utilized a formulation of...

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A search of the published medical literature revealed 2 studies investigating the researchable question:

Can piperacillin and tazobactam (Zosyn) be infused with Lactated Ringers?

Level of evidence
B - One high-quality study or multiple studies with limitations  

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[1] ZOSYN IN GALAXY CONTAINERS (tazobactam sodium and piperacillin sodium injection, solution). Prescribing information. Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.; 2023.
[2] PIPERACILLIN AND TAZOBACTAM injection, powder, for solution. Prescribing information. Apotex Corp.; 2024.
[3] Zosyn in LR Trissel's IV Compatibility [Database] Lexicomp. Available from: https://online.lexi.com/lco/action/ivcompatibility/trissels. Accessed May 14, 2024.
[4] Vallée M, Barthélémy I, Friciu M, et al. Compatibility of Lactated Ringer's Injection With 94 Selected Intravenous Drugs During Si...

InpharmD's Answer GPT's Answer

Author:gabrielle pak, PharmD, BCPS + InpharmD™ AI

INTRODUCTION BY INPHARMD™ RESEARCHER

Inflammatory bowel disease (IBD), a chronic immune disorder, has increasing global incidence and poor treatment outcome. Abnormal macrophage function is implicated in the pathophysiology of IBD. In this study, we investigated the mechanism by which human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-Ex) inhibit inflammation in IBD mouse and macrophage inflammation models.

We established a dextran sodium sulfate (DSS)-induce BALB/c mice model of IBD and treated with hucMSC-Ex via tail vein to evaluate their repair effect on IBD mice. An in vitro macrophage inflammation model was established using lipopolysaccharide (LPS) and Nigericin (Nig) by stimulating mouse macrophage RAW264.7 and human myeloid leukemia mononuclear (THP-1) cells to assess the repair effect of hucMSC-Ex on macrophage inflammation. EX 527, an effective inhibitor of silent information regulator of transcription 1 (SIRT1), was employed in both the in vivo and in vitro models to explore the effect of hucMSC-Ex on the SIRT1-FXR (farnesoid X receptor) pathway in macrophages during the attenuation of inflammation. HucMSC-Ex effectively inhibited inflammation in both the in vivo and in vitro models by up-regulating the expressions of SIRT1 and FXR, which reduced the acetylation level of FXR and inhibited the activation of NOD-like receptor thermal protein domain associated protein 3 (NLR...

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A search of the published medical literature revealed 1 study investigating the researchable question:

What are the therapeutic alternatives for the antiepileptic drug 50% & 60*2 (MFR >12) and (GDF/20) pottasium (100mg/ml)?

Level of evidence
B - One high-quality study or multiple studies with limitations  

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InpharmD's Answer GPT's Answer

Author:Chinnarao Sana, PharmD, BCPS + InpharmD™ AI

INTRODUCTION BY INPHARMD™ RESEARCHER

While the impact of the gut microbiota on brain and behavior is increasingly recognized, human studies examining this question are still scarce. The primary objective of the current study was to explore the potential relationships between the gut microbiota composition, motor cortical excitability at rest and during inhibitory control, as well as behavioral inhibition, in healthy volunteers and in patients suffering from alcohol use disorder. Motor cortical excitability was examined using a r...

Moreover, TMS was applied during a choice reaction time task to assess changes in motor excitability associated with inhibitory control. Finally, behavioral inhibition was investigated using a neuropsychological task (anti-saccade). Overall, our results highlight several interesting correlations between microbial composition and brain measures. Hence, higher bacterial diversity, as well as higher relative abundances of UGC-002 and Christensenellaceae R-7 group were correlated with stronger changes in motor excitability associated with inhibitory control. Also, higher abundance of Anaerostipes was associated with higher level of corticospinal excitability. Finally, relative abundances of Bifidobacterium and Faecalibacterium were positively related to performance in the neuropsychological task, suggesting that they might have a positive impact on behavioral inhibition. Although correlation is not causation, the present study suggests that excitatory and inhibitory brain processes migh...

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A search of the published medical literature revealed 1 study investigating the researchable question:

Exploring the links between gut microbiota and excitatory and inhibitory brain processes in alcohol use disorder: A TMS study

Level of evidence
C - Multiple studies with limitations or conflicting results  

READ MORE→

InpharmD's Answer GPT's Answer

Author:gabrielle pak, PharmD, BCPS + InpharmD™ AI

INTRODUCTION BY INPHARMD™ RESEARCHER

The effect of acupressure on pain reduction during first stage of labour

The effect of acupressure on pain reduction during first stage of labour The effect of acupressure on pain reduction during first stage of labour The effect of acupressure on pain reduction during first stage of labour The effect of acupressure on pain reduction during first stage of labour

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A search of the published medical literature revealed 0 studies investigating the researchable question:

The effect of acupressure on pain reduction during first stage of labour

Level of evidence
D - Case reports or unreliable data  

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The effect of acupressure on pain reduction during first stage of labour

Find answers, not documents.

Before InpharmD™


BeforeTime
Your team spends hours per week cobbling together literature from different studies, many behind paywalls, leaving little time for action.
BeforeTime
TI opportunities are discovered (or presented by third parties) months after the fact, resulting in costly missed savings.
BeforeTime
Decisions may be made without a complete picture, or pushed out while gathering consensus.

After InpharmD™


BeforeTime
InpharmD™ delivers customized, actionable drug information in real time, so you can focus on execution.
BeforeTime
Your team stays informed immediately when new data emerges or prices change, and you’ll always be the first to know when any changes impact your formulary.
BeforeTime
With InpharmD™, your team can make faster, more informed decisions and move forward with confidence.

What Clinical Pharmacists Are Saying...


     

Assists in our research and is a great way or us to get an answer to a medical question without spending an average of 2 hours researching UptoDate or PubMed ourselves.


  Jordan C., PharmD, New Jersey

     

Huge time saver with thorough responses.


  Jane D., PharmD, Georgia

     

I’d never heard of a DI pharmacist before, now I have one. In. My. Pocket. Amazing!


     

Holy Shhh. Cow! Holy Cow! These summaries are beautiful.


  Jane D., PharmD, Georgia

     

I just want to say: This is such a brilliant idea! You people are genius.


     

OH MY GOD WHERE HAVE YOU BEEN ALL MY LIFE!


     

I can’t tell you how much time I spend literature searching. And how I CANNOT STAND PAYWALLS. THIS IS UNBELIEVABLE!! (covers face for sec) thank you, thank you, thank you!


     

So they’re basically connecting academic researchers with front line providers and then automating everything. It’s simply brilliant.


     

The clinical pharmacist was our secret weapon anyway. (Smiles wryly) This pharmacist AI seems superhuman. I’m just blown away, honestly. (Looks at camera somberly.)


     

It’s an ENTIRE DI DEPARTMENT, that lives in Epic. Give me a second. I’m just having a hard time wrapping my head around that.


     

Sorry just give me a second, my mind is blown.


     

Stop reading and just download the app already! I’ve tried all of them. This is by far the most advanced, best-in-class.


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