​​The manufacturer of Zosyn states Lactated Ringer's Solution is compatible only with reformulated Zosyn containing EDTA and is compatible with co-administration via a Y-site. Trissel's IV compatibility database notes the older formulation without the added components (most generic products) is incompatible with Lactated Ringer's. Thus, the newer formulation is the only form of the drug mixed with this diluent. A study that tested the physical compatibility of Lactated Ringer's found compatibility with ceftriaxone, amphotericin B, and piperacillin-tazobactam after 4 hours at room temperature, but Sandoz, the manufacturer of the piperacillin-tazobactam used in the study, states that the product is incompatible with Lactated Ringer's Solution in its package insert.