Nephrogenic diabetes insipidus: a comprehensive overview

Comment by InpharmD Researcher

Nephrogenic diabetes insipidus (NDI) is a condition where the kidneys cannot concentrate urine, leading to excessive urination and thirst, despite normal or high levels of arginine vasopressin (AVP). This overview examines the clinical features, diagnosis, causes, and treatment options for NDI. The condition can be hereditary, often due to genetic mutations affecting the AVP signaling pathway, or acquired, usually linked to drug exposure (particularly lithium) or electrolyte imbalances. The management and symptoms of NDI vary depending on its cause, and the article also explores potential future therapeutic developments.

  

Nephrogenic diabetes insipidus (NDI) is characterized by the inability to concentrate urine that results in polyuria and polydipsia, despite having normal or elevated plasma concentrations of arginine vasopressin (AVP). In this study, we review the clinical aspects and diagnosis of NDI, the various etiologies,

Background

Nephrogenic diabetes insipidus (NDI) is a condition where the kidneys cannot concentrate urine, leading to excessive urination and thirst, despite normal or high levels of arginine vasopressin (AVP). This overview examines the clinical features, diagnosis, causes, and treatment options for NDI. The condition can be hereditary, often due to genetic mutations affecting the AVP signaling pathway, or acquired, usually linked to drug exposure (particularly lithium) or electrolyte imbalances. The management and symptoms of NDI vary depending on its cause, and the article also explores potential future therapeutic developments.

Nephrogenic diabetes insipidus (NDI) is a condition where the kidneys cannot concentrate urine, leading to excessive urination and thirst, despite normal or high levels of arginine vasopressin (AVP). This overview examines the clinical features, diagnosis, causes, and treatment options for NDI. The condition can be hereditary, often due to genetic mutations affecting the AVP signaling pathway, or acquired, usually linked to drug exposure (particularly lithium) or electrolyte imbalances. The management and symptoms of NDI vary depending on its cause, and the article also explores potential future therapeutic developments.

Clinical manifestations of the disease vary according to the degree of dehydration and hyperosmolality, being worse when renal water losses cannot be properly compensated by fluid intake. Regarding the diagnosis of NDI, it is important to consider the symptoms of the patient and the diagnostic tests, including the water deprivation test and the baseline plasma copeptin measurement, a stable surrogate biomarker of AVP release. Without proper treatment, patients may developcomplications leading to high morbidity and mortality, such as severe dehydration and hypernatremia. In that sense, the treatment of NDI consists in decreasing the urine output, while allowing appropriate fluid balance, normonatremia, and ensuring an acceptable quality of life. Therefore, therapeutic options include nonpharmacological interventions, including sufficient water intake and a low-sodium diet, and pharmacological treatment. The main medications used for NDI are thiazide diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs), and amiloride, used isolated or in combination.

Clinical manifestations of the disease vary according to the degree of dehydration and hyperosmolality, being worse when renal water losses cannot be properly compensated by fluid intake. Regarding the diagnosis of NDI, it is important to consider the symptoms of the patient and the diagnostic tests, including the water deprivation test and the baseline plasma copeptin measurement, a stable surrogate biomarker of AVP release. Without proper treatment, patients may developcomplications leading to high morbidity and mortality, such as severe dehydration and hypernatremia. In that sense, the treatment of NDI consists in decreasing the urine output, while allowing appropriate fluid balance, normonatremia, and ensuring an acceptable quality of life. Therefore, therapeutic options include nonpharmacological interventions, including sufficient water intake and a low-sodium diet, and pharmacological treatment. The main medications used for NDI are thiazide diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs), and amiloride, used isolated or in combination.

Relevant Prescribing Information

Clinical manifestations of the disease vary according to the degree of dehydration and hyperosmolality, being worse when renal water losses cannot be properly compensated by fluid intake. Regarding the diagnosis of NDI, it is important to consider the symptoms of the patient and the diagnostic tests, including the water deprivation test and the baseline plasma copeptin measurement, a stable surrogate biomarker of AVP release. Without proper treatment, patients may developcomplications leading to high morbidity and mortality, such as severe dehydration and hypernatremia. In that sense, the treatment of NDI consists in decreasing the urine output, while allowing appropriate fluid balance, normonatremia, and ensuring an acceptable quality of life. Therefore, therapeutic options include nonpharmacological interventions, including sufficient water intake and a low-sodium diet, and pharmacological treatment. The main medications used for NDI are thiazide diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs), and amiloride, used isolated or in combination.

References:

Kavanagh, C, Uy, NS. Nephrogenic diabetes insipidus. Pediatr Clin 2019;66:227–34. https://doi.org/10.1016/j.pcl.2018.09.006.

Christ-Crain, M, Bichet, DG, Fenske, WK, Goldman, MB, Rittig, S, Verbalis, JG, et al.. Diabetes insipidus. Nat Rev Dis Prim 2019;5:54. https://doi.org/10.1038/s41572-019-0103-2.

D’Alessandri-Silva, C, Carpenter, M, Ayoob, R, Barcia, J, Chishti, A, Constantinescu, A, et al.. Diagnosis, treatment, and outcomes in children with congenital nephrogenic diabetes

Literature Review

A search of the published medical literature revealed 1 study investigating the researchable question:

Nephrogenic diabetes insipidus: a comprehensive overview

Level of evidence

B - One high-quality study or multiple studies with limitations  Read more→



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